Expression Profiling

Gene expression analysis is a way of monitoring the activity of genes as a result of normal cellular function, disease states or changes in the environment. Expression analysis aids the drug development process by identifying new drug targets, aiding the discovery and validation of clinical biomarkers linked to human disease, monitoring disease progression, predicting the function of novel genes, understanding variability in response to drugs and predicting the toxicity of drugs. Depending on the scale performed, expression profiling can examine one specific gene of interest or thousands of genes at once to create an overall picture of cellular function.

Analysis of gene expression typically involves measuring the relative amount of mRNA expressed in two or more experimental conditions and is generally performed using microarrays or real-time PCR.There are also methods available to examine epigenetic control of gene expression. With QPS, you are assured of top-quality starting material for successful downstream molecular applications.QPS offers automated RNA isolation and banking from many matrices, including whole blood, plasma, serum, tissues, FFPE biopsy sections or cultural cells.QPS utilizes leading technology platforms for gene expression analysis including Applied Biosystems’ TaqMan® platform for real-time PCR (including TaqMan low density arrays), Affymetrix Genechip® microarrays and Pyrosequencing® for identification of DNA methylation status.We also perform western blot analysis, functional assays and cell-based assays.