Autoradiography
Tissue Distribution and Autoradiography
An autoradiograph is an image produced by the radiation emitted from a specimen, such as a section of tissue, that has been treated or injected with a radiolabeled isotope or that has absorbed or ingested such an isotope. QPS performs GLP and non-GLP small and large-animal tissue distribution studies using autoradiography to support drug development and new drug applications.
Full ranges of autoradiography capabilities are available:
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Quantitative and qualitative whole body tissue distribution studies
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Predictions of human radioactive dosimetry for clinical radiolabeled mass balance studies
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Qualitative micro-autoradiography coupled with quantitative autoradioluminography
Tissue Distribution Quantitative Whole-Body Autoradiography (QWBA)
QWBA offers unique insights for investigators by answering key questions related to tissue pharmacokinetics and metabolism, pathology, toxicology, drug delivery and disposition. QWBA studies provide the tissue distribution and pharmacokinetics data required for new drug registration and for predicting human exposure to radioactivity during clinical radiolabeled mass balance studies.
Tissue Distribution and Micro-Autoradiography
Micro-autoradiography is a useful tool for visualizing the location of radiolabeled material at the cellular level.
