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Validated Assays

Services > Bioanalysis > Small Molecules

Small Molecules

Small Molecule Quantitation Using LC-MS/MS

 

LC-MS/MS is the method of choice for small molecule drug quantitation because, by definition, any molecules that can be ionized and detected can be quantitated using LC-MS/MS. Although most of the LC-MS/MS methods developed and validated by QPS are for traditional small molecule drugs, we have also developed and validated LC-MS/MS assays for large multiple-charged molecules such as polypeptides and oligonucleotides.

 

QPS has significant experience with various chemical structures in multiple therapeutic areas. With the increasing emphasis on “active” isomers and “active” metabolites, over 80% of our NCE studies are in the “N-in-1” format and about 15% of our new assays are chiral studies.

 

Equipment

 

QPS currently has 30 LC-MS/MS instruments between QPS Delaware and QPS Taiwan operations. QPS Delaware has 19 API 4000 triple quadrupoles mass spectrometers, as well as UPLC, LC/UV and LC/fluorescent instruments dedicated to regulated studies. Seven other LC-MS/MS instruments, including six API 4000 triple quadrupoles and linear ion trap, are dedicated to discovery, non-regulated and metabolite identification studies. QPS Taiwan has four API 4000 triple quadrupoles for bioanalysis studies.