DMPK
Drug Metabolism and Pharmacokinetics (DMPK) Overview
Studies determining Absorption, Distribution, Metabolism and Excretion (ADME) patterns in laboratory animals and humans are an integral part of the Drug Metabolism and Pharmacokinetics (DMPK) services provided by QPS. These studies are employed at the discovery, candidate selection, Investigational New Drug (IND) enabling and New Drug Application (NDA) stages of a development program.
Many New Chemical Entities (NCEs) can be rapidly screened using the discovery Pharmacokinetics (PK) approach, resulting in more efficient identification of candidates with the most desired ADME properties. By optimizing the lead structures during the candidate selection process, QPS helps to select drug candidates with the best chance of success. Completion of the preclinical DMPK and clinical PK studies will provide an ADME data package that will fully support regulatory IND and NDA submission.
In addition to conducting animal PK studies, QPS performs a comprehensive series of biotransformation and Quantitative Whole-Body Autoradiography (QWBA) studies.
